Author

Gianluca Sigismondo

German Cancer Research CenterORCID 0000-0002-0722-3210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jeroen KrijgsveldiD· 3 shared Alexandra Eliassaf· 1 shared Anna Sueki· 1 shared Annika HausmanniD· 1 shared Athanasios TypasiD· 1 shared Aurélie ErnstiD· 1 shared Bachir El Debs· 1 shared Batsheva KeremiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Jeroen KrijgsveldORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology

Isolation of proteins on chromatin (iPOC) reveals signaling pathway-dependent alterations in the DNA-bound proteome

Huiyu Wang, Syed Azmal Ali, Jeroen Krijgsveld, Gianluca Sigismondo

The paper introduces iPOC, a method to isolate DNA-bound proteins, and applies it to study changes in the DNA-bound proteome upon perturbation of the PI3K/AKT/mTOR pathway.

Molecular & Cellular Proteomics · Jan 20, 2025Peer-reviewedMolecular Biology

Spatiotemporal proteomics uncovers cathepsin-dependent host cell death during bacterial infection

Joel Selkrig, Nan Li, Jacob Bobonis, Annika Hausmann, Anna Sueki, Haruna Imamura, Bachir El Debs, Gianluca Sigismondo, Bogdan I. Florea, Herman S. Overkleeft, Pedro Beltrão, Wolf‐Dietrich Hardt, Jeroen Krijgsveld, Athanasios Typas

The paper quantifies host proteome dynamics during Salmonella infection, revealing cathepsin-dependent cell death mechanisms.

bioRxiv · Nov 7, 2018 · PreprintSystems Biology