Author

Joseph Pascucci

Boston Children's HospitalORCID 0000-0002-8350-7039Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:zebrafish· 2 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Annapurna PoduriiD· 2 shared Christopher M. LaCoursiereiD· 2 shared Hyun Yong KohiD· 2 shared Parul ChaudharyiD· 2 shared Sneham TiwariiD· 2 shared Chariton MoschopoulosiD· 1 shared Hannah HepneriD· 1 shared Lacey A. SmithiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Annapurna PoduriORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 4, 2026

CAMSAP3 loss of function models suggest causative role in generalized genetic epilepsy

Christopher M. LaCoursiere, Zachary Stayn, Hannah Hepner…·Annapurna Poduri

The paper shows that CAMSAP3 loss of function leads to microtubule acetylation dysregulation and epileptic features in zebrafish and cultured cells.

DOI 10.64898/2026.09.01.744686

zebrafishwhole-exome sequencing

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 9, 2025

Early death and neuronal abnormalities in depdc5 loss-of-function mosaic zebrafish models

Sneham Tiwari, Christopher M. LaCoursiere, Hyun Yong Koh…·Annapurna Poduri

This study generates mosaic depdc5 loss-of-function zebrafish models to study DEPDC5-related epilepsy and early death, finding increased seizure-like behavior and neuronal hyperexcitability.

DOI 10.64898/2025.12.04.692362

zebrafishexperimental assay

𝕏 PostBluesky