Christopher M. LaCoursiere

The paper shows that CAMSAP3 loss of function leads to microtubule acetylation dysregulation and epileptic features in zebrafish and cultured cells.

This study generates mosaic depdc5 loss-of-function zebrafish models to study DEPDC5-related epilepsy and early death, finding increased seizure-like behavior and neuronal hyperexcitability.

The paper generates zebrafish models of candidate human epilepsy genes and identifies five genes associated with seizure-like behavior and hyperexcitability.