Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability
Jesse Coker, Rong Sun, Paul M. Polzer, Todd Romigh, Christopher M. Goins, Nancy S. Wang, Jae U. Jung, Shaun R. Stauffer
The paper identifies false positive inhibitors of NSP14 ExoN due to contaminating divalent cations, highlighting challenges in fragment-based drug development for this target.
ACS Chemical Biology · Feb 16, 2026Peer-reviewedBiochemistry