HSPB8 regulates CTP synthase filaments to couple nucleotide metabolism and autophagy in tumors
Chun-Yen Wang, Wei-Cheng Lin, Kuang-Jing Huang, Archan Chakraborty, Yu-Tsun Lin, Ya‐Ju Hsieh, Kun‐Yi Chien, Po‐Yuan Ke, Weicheng Huang, Chih-Yun Cheng, Ian Yi‐Feng Chang, Hsiang-Yu Tang, Cheng-Hung Yang, M. D. Ming-Huei Cheng, Ying Chang, , Li‐Mei Pai
This study identifies HSPB8's role in regulating CTP synthase filaments to link nucleotide metabolism and autophagy in tumors, showing that disrupting these filaments impairs tumor growth and correlates with poor patient survival.
bioRxiv · Jul 1, 2026 · PreprintCell Biology