Archan Chakraborty

This study identifies HSPB8's role in regulating CTP synthase filaments to link nucleotide metabolism and autophagy in tumors, showing that disrupting these filaments impairs tumor growth and correlates with poor patient survival.

The paper introduces iSPy, an unsupervised learning pipeline for spatial ploidy inference from intact tissue images, demonstrating its use in Arabidopsis, Drosophila, and human tissues.

The paper identifies COX7A as a regulator of cardiac polyploidy by modulating mitochondrial integrity, showing opposing roles in heart and salivary gland tissues.

The paper identifies a gene that promotes viability in cells with centrosome amplification and multipolar division by positioning centrosomes at the plasma membrane.

The paper identifies Loofah, an adhesion protein, as a suppressor of cell death in long-lived Drosophila hindgut enterocytes by maintaining FasIII membrane localization.

This paper introduces ReFLeCT, a high-speed volumetric fluorescence imaging technique that captures 4D videos of freely moving zebrafish and Drosophila larvae with high-resolution 3D reconstruction.

This study identifies conserved polyploidy asymmetry between cardiac chambers in Drosophila and humans, showing its role in maintaining heart function and its implications for heart failure.