Systems BiologybioRxivPreprint
Biphasic JNK-Erk Signaling Separates Induction and Maintenance of Cell Senescence after DNA Damage
Tatiana S. Netterfield, Gerard J. Ostheimer, Andrea R. Tentner…·Michael B. Yaffe
The paper shows JNK and Erk signaling pathways have distinct roles in initiating and maintaining cell senescence after DNA damage through AP-1 and the senescence-associated secretory phenotype.
DOI 10.1101/2022.06.15.496288