Michael B. Yaffe

This study shows that etoposide-treated B16-Ova melanoma cells upregulate B2M and lose tumor-forming potential while remaining viable and stimulating T-cell activation.

This study shows MK2 promotes resolution of colonic inflammation by enabling the switch to specialized pro-resolving mediators, improving inflammation outcomes and tissue repair.

The paper uses phosphoproteomic data and KMEA to identify tumor-specific kinase activity in GEP-NETs, revealing potential therapeutic targets.

This study shows that MK2 regulates CD8 T cell inflation during CMV infection by affecting their expansion and differentiation.

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

The paper shows JNK and Erk signaling pathways have distinct roles in initiating and maintaining cell senescence after DNA damage through AP-1 and the senescence-associated secretory phenotype.

The paper introduces DSB-Spectrum reporters to analyze DNA repair pathway cross-talk and shows that DNA-PKcs inhibition increases SSA and HR, while end-resection factors influence pathway competition.

Transite identifies RNA-binding proteins modulating gene expression changes by analyzing RNA stability and degradation, validated with hnRNPC in chemotherapeutic resistance.

This study reveals a hierarchical organization in the kinase domain that enables regulatory plasticity through distinct functional units.