Guy Twa

Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns

This study demonstrates using sex-dependent gene expression patterns to accurately deconvolve pooled snRNA-seq data, achieving 93-95% accuracy in cell sex classification.

Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling

This study identifies morphine-induced transcriptional changes in VTA glial cells and dopamine neurons, revealing glucocorticoid-mediated regulation of Fkbp5 in astrocytes.

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

This study investigates the gut microbiome's role in Parkinson's disease using metagenomics, finding widespread dysbiosis and associations with disease mechanisms.