Author
University Medical Center GroningenORCID 0000-0002-7546-0867Unclaimed ORCID profile · follow to get notified of new preprints
16 papers
Recent·Most cited
Li Li, Zhixin Tang, Zhong Z, Tingting Geng, Yanjun Guo, Yunfei Liao, Ayşe Demirkan, Jack Bowden, Fiona Bragg, An Pan, Xufang Sun, Jiang Liu, Gang Liu, Jun Liu
This study identifies C1R as a molecular link between coronary artery disease and dementia through proteogenomic analysis of circulating proteins and genetic causal-inference.
medRxiv · Jul 16, 2026 · PreprintGenetic & Genomic Medicine
Vincent Pascat, Liudmila Zudina, Lucas Maurin, Anna Ulrich, Jared G. Maina, Ayşe Demirkan, Zhanna Balkhiyarova, Igor Pupko, Yevheniya Sharhorodska, François N. Pattou, Bart Staels, Marika Kaakinen, Amna Khamis, Amélie Bonnefond, Patricia B. Munroe, , Inga Prokopenko
The paper identifies genetic clusters underlying T2D and hypertension comorbidity using partitioned polygenic scores, improving risk prediction for individuals with heightened susceptibility.
medRxiv · Mar 2, 2025 · PreprintGenetic & Genomic Medicine
Ayşe Demirkan, Jenny van Dongen, Casey T. Finnicum, Harm-Jan Westra, Soesma A. Jankipersadsing, Gonneke A. H. M. Willemsen, Richard G. IJzerman, Dorret Irene Boomsma, Erik A. Ehli, Marc Jan Bonder, Jingyuan Fu, Lude Franke, Cisca Wijmenga, Eco J. C. de Geus, Alexander Kurilshikov, Alexandra Zhernakova
This study identifies two CpGs associated with the gut microbiome genus Eggerthella and shows microbiome mediates environmental effects on DNA methylation.
bioRxiv · Nov 3, 2023 · PreprintGenomics
Zachary D. Wallen, Ayşe Demirkan, Guy Twa, Gwendolyn Cohen, Marissa N. Dean, David G. Standaert, Timothy Robert Sampson, Haydeh Payami
This study investigates the gut microbiome's role in Parkinson's disease using metagenomics, finding widespread dysbiosis and associations with disease mechanisms.
Nature Communications · Nov 14, 2022Peer-reviewedGenomics
Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver‐Williams, Eeva Sliz, Elias Allara, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko V Salomaa, Matt Goodwin, David A. Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, , Johannes Kettunen
This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.
medRxiv · Oct 20, 2022 · PreprintGenetic & Genomic Medicine
Saqib Hassan, Marika Kaakinen, Harmen H. M. Draisma, Liudmila Zudina, Mohd Ashraf Ganie, Aafia Rashid, Zhanna Balkhiyarova, George Seghal Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayşe Demirkan, Inga Prokopenko
The paper identifies enriched gut microbiome genera in Kashmiri women with PCOS, linking them to metabolic and hormonal factors.
Genes · Feb 18, 2022Peer-reviewedGenomics
Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders Ulrik Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D. Arias, Ronen E. Mukamel, Cassandra Nichole Spracklen, Xianyong Yin, , Thomas Folkmann Hansen
This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.
bioRxiv · Jan 7, 2022 · PreprintGenetics
Vasiliki Lagou, Longda Jiang, Anna Ulrich, Liudmila Zudina, Karla Sofia Gutiérrez González, Zhanna Balkhiyarova, Alessia Faggian, Shiqian Chen, Petar V. Todorov, Sodbo Sharapov, Alessia David, Letizia Marullo, Reedik Mägi, Roxana‐Maria Rujan, Emma Ahlqvist, , Inga Prokopenko
This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.
medRxiv · Apr 17, 2021 · PreprintGenetic & Genomic Medicine
Alexander Kurilshikov, Carolina Medina‐Gómez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayşe Demirkan, Caroline Ivanne Le Roy, Juan A. Raygoza Garay, Casey T. Finnicum, Xingrong Liu, Daria V. Zhernakova, Marc Jan Bonder, Tue H. Hansen, Fabian Frost, Malte Christoph Rühlemann, , Oluf Borbye Pedersen
The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.
Nature Genetics · Jan 18, 2021Peer-reviewedGenetics
Ji Chen, Cassandra Nichole Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’an Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud Boutin, Reedik Mägi, Johannes Waage, Achilleas Pitsillides, Ruifang Li‐Gao, , Michael H Preuss
This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.
bioRxiv · Jul 23, 2020 · PreprintGenetics
Natasha Hui Jin Ng, Sara M. Willems, Juan Fernandez, Rebecca S. Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaëlle Marenne, Jana K. Rundle, Xueling Sim, Hanieh Yeghootkar, Nicola L. Beer, Anne Raimondo, Andrei I. Tarasov, Soren K. Thomsen, , Abbas Dehghan
The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.
bioRxiv · Oct 3, 2019 · PreprintGenetics
Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning W. Tiemeier, Janine F. Felix, , Cornelia M. van Duijn
This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.
Nature Communications · Jun 13, 2019Peer-reviewedGenomics
Harmen H. M. Draisma, Jun Liu, Igor Pupko, Ayşe Demirkan, Zhanna Balkhiyarova, Andrew P. Morris, Reedik Mägi, Matthias Wielscher, Saqib Hassan, Cornelia M. van Duijn, Sylvain P Sebert, Marjo‐Riitta Järvelin, Marika Kaakinen, Inga Prokopenko
The paper introduces methylSCOPA and META-methylSCOPA software for multi-phenotype epigenome-wide association studies, identifying significant methylation sites associated with fasting glucose and insulin levels.
bioRxiv · Jun 3, 2019 · PreprintBioinformatics
Ayşe Demirkan, Jun Liu, Najaf Amin, Ko Willems van Dijk, Cornelia M. van Duijn
This study examines how inbreeding affects type 2 diabetes-related metabolites in a Dutch genetic isolate, finding that inbreeding influences 32.9% of T2DM-related metabolites independently of BMI.
bioRxiv · Apr 25, 2019 · PreprintGenetics
Ayşe Demirkan, Jun Liu, Najaf Amin, Jan Bert van Klinken, Ko Willems van Dijk, Cornelia M. van Duijn
The paper identifies recessive genetic variants associated with type 2 diabetes-related metabolites in a consanguineous population.
bioRxiv · Apr 25, 2019 · PreprintGenetics
Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, Nigel William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A. Jensen, Yao Hu, , Jun Liu
This study identifies 16 causal coding variants in type 2 diabetes using fine-mapping and shows that one third of signals are false leads.
Nature Genetics · Apr 1, 2018Peer-reviewedGenetics