David G. Standaert

This study identifies dysbiotic gut microbiome features in Parkinson's disease, links them to genetic variants, and proposes microbiome-based biomarkers for targeted treatment.

This study identifies genetic variants associated with Parkinson's disease in African and African admixed populations, highlighting differences from European and Asian populations.

The paper examines T cell responses to PINK1 and α-synuclein in prodromal Parkinson's disease, finding elevated reactivity comparable to clinically diagnosed PD.

This study shows that alpha-synuclein overexpression in mice alters gut microbiome composition with age, suggesting a potential link between PD pathology and microbiome dysbiosis.

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

The paper investigates cholinergic transmission in a mouse model of dystonia, finding that D2R-mediated paradoxical excitation of cholinergic interneurons is reversed by caffeine, suggesting a role in movement regulation.

This study identifies differential activation states of D1-MSN subpopulations in response to L-DOPA treatment and links these changes to LID development through activin/TGFβ signaling.

Intronic GBA1 variant rs3115534-G, common in African and African admixed ancestry but rare elsewhere, raises Parkinson's disease risk (OR 1.58) and lowers onset age.

This study identifies border-associated macrophages (BAMs) as key mediators of alpha-synuclein-induced neuroinflammation in Parkinson's disease.

This study investigates the gut microbiome's role in Parkinson's disease using metagenomics, finding widespread dysbiosis and associations with disease mechanisms.

The paper shows that genetic variants at the alpha-synuclein locus influence gut microbiome dysbiosis in Parkinson's disease.

This study identifies three clusters of gut microbiota associated with Parkinson's disease, including overabundance of opportunistic pathogens.

The paper identifies a clinical phenotype in Parkinson's disease patients that predicts early development of postural instability and cognitive decline.