BiophysicsNature CommunicationsPeer-reviewed
Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes
Ning Ma, S. Bhattacharya, Sanychen Muk…·Nagarajan Vaidehi
This study shows that frustration in the SMARCA2-VHL protein-protein interface correlates with PROTAC cooperativity, offering a framework for structure-based PROTAC design.
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