S. Bhattacharya

This study combines live-cell imaging and mathematical modeling to show how cancer cells adapt to stress in spatially confined environments, revealing cooperative and competitive strategies influenced by spatial organization and microenvironment dynamics.

The paper uses long-read sequencing to identify novel lncRNAs generated by SF3B1 mutation and shows they produce functional peptides linked to cancer prognosis.

This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

The paper investigates how developmental DNA damage responses in α- and β-cells contribute to their differential susceptibility to diabetes, showing β-cells have higher DNA damage vulnerability and repair efficiency.

DRUMBEAT is a machine learning model that identifies time-resolved cooperative events in protein dynamics, revealing folding pathways and critical residues.

This study uses NMR and MD simulations to analyze conformational entropy changes in GPCRs, showing how dynamic fluctuations influence allosteric signaling and receptor function.

This paper develops an interpretable machine learning model to identify residue communities involved in GPCR conformational transitions, with applications to dopamine receptor subtype-specific drug design.

This study shows that frustration in the SMARCA2-VHL protein-protein interface correlates with PROTAC cooperativity, offering a framework for structure-based PROTAC design.

This study reveals the conformational dynamics of Paxillin's N-domain interacting with FAK's FAT domain, showing a multi-state complex with functional implications.

BaNDyT uses Bayesian network modeling to analyze molecular dynamics trajectories, providing data-driven insights into protein function and interactions.

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

This study identifies DNA methylation as a mechanism restricting TH+ β-cell subpopulation in pancreatic islets, showing its role in β-cell heterogeneity and identity maintenance.