Author

Keith Le

Beckman Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 1

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Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alessio CiulliiD· 1 shared Andreas BergneriD· 1 shared Christiane C. KofinkiD· 1 shared Emelyne DiersiD· 1 shared Gerd BaderiD· 1 shared Harald WeinstabliD· 1 shared Kyra Sankar· 1 shared Michael J. RoyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alessio CiulliORCID

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1 paper

Recent·Most cited

Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes

Ning Ma, S. Bhattacharya, Sanychen Muk, Zuzana Jandová, Philipp S. Schmalhorst, Soumadwip Ghosh, Keith Le, Emelyne Diers, Nicole B. Trainor, William Farnaby, Michael J. Roy, Christiane C. Kofink, Peter Greb, Harald Weinstabl, Alessio Ciulli, , Nagarajan Vaidehi

This study shows that frustration in the SMARCA2-VHL protein-protein interface correlates with PROTAC cooperativity, offering a framework for structure-based PROTAC design.

Nature Communications · Sep 29, 2025Peer-reviewedBiophysics