Limitations of pupil diameter as a proxy for modes of locus coeruleus activity
Lowell W. Thompson, Siddhartha Joshi, Joshua I. Gold
This study shows that pupil diameter is not reliably linked to locus coeruleus activity modes, suggesting caution in using pupil size as a proxy for phasic and tonic LC-NE activity.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience