Cancer BiologyNature GeneticsPeer-reviewed
Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer
Xiaodong Lü, Viriya Keo, Irina Cheng…·Jindan Yu
This study identifies NKX2-1-driven epigenetic and 3D chromatin remodeling as key to neuroendocrine prostate cancer progression and reveals CBP/p300 inhibitors as potential therapeutic targets.