Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer
Xiaodong Lü, Viriya Keo, Irina Cheng, Wanqing Xie, Galina Gritsina, Juan Wang, Lina Lu, Cheng-Kai Shiau, Yueying He, Qiushi Jin, Peng Jin, Martin George Sanda, Victor G. Corces, Nicolas Altemose, Ruli Gao, , Jindan Yu
This study identifies NKX2-1-driven epigenetic and 3D chromatin remodeling as key to neuroendocrine prostate cancer progression and reveals CBP/p300 inhibitors as potential therapeutic targets.
Nature Genetics · Jul 21, 2025Peer-reviewedCancer Biology