SARS-CoV-2 spike protein induces long-term TLR4-mediated synapse and cognitive loss recapitulating Post-COVID syndrome
Fabrícia Lima Fontes-Dantas, Gabriel Gripp Fernandes, Elisa Gouvea Gutman, Emanuelle Vasconcellos de Lima, Leticia S. Antonio, Mariana Beiral Hämmerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana Maria Bernardino Araújo, Talita Nascimento da Silva, Larissa Araújo Duarte, Andreza Lemos Salvio, Karina Lebeis Pires, Luciane Almeida Amado Leon, Cláudia Cristina Ferreira Vasconcelos, , Cláudia Pinto Figueiredo
The paper shows that SARS-CoV-2 spike protein causes long-term cognitive and synaptic damage in mice, and a TLR4 genetic variant is linked to worse cognitive outcomes in post-COVID patients.
bioRxiv · Jun 7, 2022 · PreprintNeuroscience