PhysiGym: bridging the gap between the Gymnasium reinforcement learning application interface and the PhysiCell agent-based model software
A. Bertin, Elmar Bucher, Owen OG Griere, Miguel Hurtado, Heber Lima da Rocha, Randy W. Heiland, Aneequa Sundus, Paul Macklin, Vincent François-Lavet, Emmanuel Rachelson, Véra Pancaldi
PhysiGym integrates PhysiCell with Gymnasium to enable reinforcement learning control of in silico biological processes, demonstrating tumor elimination in a case study.
bioRxiv · Sep 18, 2025 · PreprintBioinformatics