Christine A. F. Von Arnim

This study examines the interactions between A{beta}, tau, LATE-NC, -synuclein, and APOE {varepsilon}4 in 480 post-mortem brains, finding that tau is the strongest predictor of neurodegeneration while LATE-NC primarily affects hippocampal neuron loss.

This study shows that amygdala-predominant α-synuclein pathology is linked to reduced hippocampal neuron density in Alzheimer's disease, mediated through pTau and LATE-NC.