Sandra O. Tomé

This study examines the interactions between A{beta}, tau, LATE-NC, -synuclein, and APOE {varepsilon}4 in 480 post-mortem brains, finding that tau is the strongest predictor of neurodegeneration while LATE-NC primarily affects hippocampal neuron loss.

This study shows that pathological tau spreads from the olfactory epithelium to brain regions in AD models and suggests targeting the olfactory epithelium to slow tauopathy progression.

This study shows that amygdala-predominant α-synuclein pathology is linked to reduced hippocampal neuron density in Alzheimer's disease, mediated through pTau and LATE-NC.