Andrew R. Latchford

The paper analyzes UK Biobank data to assess the association of APC I1307K variant with colorectal cancer risk in Ashkenazi and non-Ashkenazi whites, finding no significant association and highlighting the need for larger studies.

This paper reviews the phenotypic spectrum of MUTYH-associated polyposis (MAP) to clarify associations between pathogenic MUTYH variants and various cancers and extracolonic manifestations.

The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.