Author

Ryan O. Schenck

Centre for Human GeneticsORCID 0000-0002-0294-0106Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:whole-exome sequencing· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alexander R.A. AndersoniD· 2 shared Chandler GatenbeeiD· 2 shared Eszter LakatosiD· 2 shared Trevor A. GrahamiD· 2 shared Aaron M. HorningiD· 1 shared Agata XellaiD· 1 shared Alison BerneriD· 1 shared Andrew R. LatchfordiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Alexander R.A. AndersonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan, Aaron M. Horning, Shanlan Mo, Clemens L. Weiß, Edward D. Esplin, Winston R. Becker, Si Wu, Casey Ryan Hanson, Nasim Bararpour, Lihua Jiang, Kévin Contrepois, Hayan Lee, Stephanie A. Nevins, , Christina N. Curtis

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

Nature · Nov 25, 2025Peer-reviewedCancer Biology

Controlling treatment toxicity in ovarian cancer to prime the patient for tumor extinction therapy

Kit Gallagher, Rachel S Sousa, Chandler Gatenbee, Ryan O. Schenck, Peng Chen, Timon Citak, Sydney Leither, Lucia Mazzacurati, Agata Xella, Zoe Zhou, Dawn Lemanne, Paulo C. Rodrı́guez, Erin M. George, Maximilian A.R. Strobl

This paper develops computational frameworks to design personalized multi-strike therapies for ovarian cancer that reduce toxicity while enhancing tumor extinction.

bioRxiv · Jul 10, 2025 · PreprintCancer Biology

Reconstruction of Contemporary Human Stem Cell Dynamics with Oscillatory Molecular Clocks

Calum Gabbutt, Ryan O. Schenck, Daniel J. Weisenberger, Christopher Kimberley, Alison Berner, Jacob Househam, Eszter Lakatos, Mark Robertson‐Tessi, Isabel Rodríguez Martín, Roshani Patel, Susan K. Clark, Andrew R. Latchford, Chris P. Barnes, Simon John Leedham, Alexander R.A. Anderson, , Darryl K. Shibata

The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.

Nature Biotechnology · Jan 3, 2022Peer-reviewedBioinformatics

NeoPredPipe: High-Throughput Neoantigen Prediction and Recognition Potential Pipeline

Ryan O. Schenck, Eszter Lakatos, Chandler Gatenbee, Trevor A. Graham, Alexander R.A. Anderson

NeoPredPipe predicts and assesses neoantigen recognition potential from tumor variants in single and multi-region samples, providing insights into neoantigen burden and tumor heterogeneity.

BMC Bioinformatics · May 22, 2019Peer-reviewedBioinformatics