Engineering a PD-L1-sensing synthetic receptor for programmable macrophage-mediated phagocytosis
Ilaria De Martino, Luigi Russo, Matteo Marchetti, Velia Siciliano
This paper engineers a synthetic receptor that detects PD-L1 on cancer cells, enabling macrophages to block CD47 signals and enhance phagocytosis.
bioRxiv · Jan 21, 2026 · PreprintSynthetic Biology