Velia Siciliano

This study identifies stage-specific lncRNA reprogramming in p53-deficient human neural differentiation and glioma organoids, highlighting potential biomarkers for glioblastoma.

This paper engineers a synthetic receptor that detects PD-L1 on cancer cells, enabling macrophages to block CD47 signals and enhance phagocytosis.

The paper identifies small molecules that enhance gene expression in synthetic circuits by analyzing RNA-seq data and drug-induced profiles.

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

The paper designs synthetic promoters that respond to TFs differentially expressed in activated and exhausted T cells, enabling functional state classification and dynamic gene expression control.

The paper quantifies resource load from genetic constructs in mammalian cells and provides a framework for designing more efficient synthetic circuits.

This paper develops an endoribonuclease-based feedforward loop to improve modularity in genetic systems by reducing resource competition in mammalian cells.

This study identifies gene expression burden in mammalian cells and introduces miRNA-based circuits to mitigate it, improving synthetic circuit performance.