Cancer BiologybioRxivPreprint
RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma
Elizabeth A. Mendes, Aanandi Munshi, Archana Singh…·Corinne Mary Linardic
This study identifies RUNX2 as a druggable target in fusion-positive rhabdomyosarcoma, showing its inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and reduces tumor growth.
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