Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove
Christina Alexandra Stephens, Niek van Hilten, Lisa Zheng, Michael Grabe
This study uses simulations to show that TMEM16 proteins primarily scramble lipids in an open groove when Ca2+ is bound, but also do so at the dimer interface when Ca2+ is absent.
bioRxiv · Sep 25, 2024 · PreprintBiophysics