Niek van Hilten

This paper uses molecular dynamics simulations to show that hydrophobic mismatch between transmembrane proteins and lipid membranes leads to lipid sorting based on tail unsaturation.

The paper identifies a narrow thermodynamic design window for amphipathic peptides to selectively permeabilize viral membranes while sparing host cells, using a physics-driven generative workflow.

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

The paper develops a cell-based phospholipid scrambling assay to show that TMEM16F preferentially scrambles phosphatidylserine and phosphatidylcholine over phosphatidylethanolamine.

This study uses simulations to show that TMEM16 proteins primarily scramble lipids in an open groove when Ca2+ is bound, but also do so at the dimer interface when Ca2+ is absent.