Christina Alexandra Stephens

The paper uses molecular dynamics simulations and electrophysiology to study conformational changes in TMEM16A upon inhibitor removal, revealing conductive and non-conductive states and mechanisms of Ca2+-dependent gating.

This study determines the structure of LRRC8A:D VRACs using cryo-EM, revealing lipid-gating and subunit-specific structural features.

This paper designs dynamic proteins with switch-like behavior using deep learning, validated by structure solving and simulations showing controllable conformational changes.

This study uses simulations to show that TMEM16 proteins primarily scramble lipids in an open groove when Ca2+ is bound, but also do so at the dimer interface when Ca2+ is absent.