Actin polymerization drives lumen formation in a human epiblast model
Dhiraj Indana, A. P. Zakharov, Youngbin Lim, Alexander R. Dunn, Nidhi Bhutani, Vivek B. Shenoy, Ovijit Chaudhuri
This study identifies actin polymerization as the mechanism driving lumen formation in human epiblast models, showing it initiates lumen opening and transitions to pressure-driven growth as the lumen expands.
bioRxiv · Apr 20, 2023 · PreprintDevelopmental Biology