Ovijit Chaudhuri

Hydrogel confinement of the secreted nascent matrix imposes solid stress and mediates pathology of chondrocytes

This study shows that chondrocytes respond to solid stress from their nascent matrix in hydrogels, leading to inflammatory and migratory responses associated with osteoarthritis.

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

Mechanical Checkpoint for Cell Division in Three-Dimensional Microenvironments

The paper identifies three modes of ECM resistance during cell division in 3D microenvironments and highlights the dominance of pericellular shear resistance.

T Cells Tear Apart Confining Extracellular Matrix Via a Breaststroke-like Motion to Generate Migration Paths

This study shows T cells generate migration paths in confining ECMs by tearing them apart with breaststroke-like motion, finding that shear strength, not stiffness or pore size, correlates with migration.

Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.

This study shows that epithelial monolayers migrate faster on viscoelastic substrates with slower stress relaxation, due to increased fluidity and leader cell formation.

Glassy Adhesion Dynamics Govern Transitions Between Sub-Diffusive and Super-Diffusive Cell Migration on Viscoelastic Substrates

This study investigates how viscoelastic substrate properties influence cell migration, revealing transitions between sub-diffusive and super-diffusive behavior through a new glassy motor-clutch model.

Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion

This study shows that swirling motion of breast cancer cells aligns collagen fibers radially, enabling collective invasion by generating contractile stresses.

Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Actin polymerization drives lumen formation in a human epiblast model

This study identifies actin polymerization as the mechanism driving lumen formation in human epiblast models, showing it initiates lumen opening and transitions to pressure-driven growth as the lumen expands.