Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Yanshu Wang, Amir Rattner, Zhongming Li, Philip M. Smallwood, Jeremy Nathans
This study shows that loss of TGF-beta signaling in vascular endothelial cells in mice causes choroidal neovascularization and CNS vascular inflammation, with significant immune cell infiltration and pro-inflammatory changes.
eLife · Dec 23, 2025Peer-reviewedNeuroscience