Author

Philip M. Smallwood

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Amir RattneriD· 3 shared Jeremy NathansiD· 3 shared Yanshu WangiD· 3 shared Ningyu Zhu· 1 shared Philip V SeegreniD· 1 shared Zhongming LiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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3 shared papersDevelopmental Biology

Amir RattnerORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintSep 7, 2026

Wnt/beta-catenin signaling regulates Vascular Endothelial Growth Factor (VEGF) receptors in central nervous system endothelial cells

Yanshu Wang, Ningyu Zhu, Amir Rattner…·Jeremy Nathans

This study shows that Wnt/beta-catenin signaling modulates VEGF receptor levels in CNS endothelial cells, thereby regulating VEGF signaling.

DOI 10.64898/2026.09.03.745507

mouseexperimental assay

𝕏 PostBluesky

ImmunologyeLifePeer-reviewedAug 7, 2026

TLR4 signaling drives tissue inflammation, Claudin-5 internalization,and vascular barrier breakdown in a mouse model of neonatal meningitis

Philip V Seegren, Amir Rattner, Philip M. Smallwood…·Jeremy Nathans

DOI 10.7554/elife.110458.4

mousebulk RNA-seq

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NeuroscienceeLifePeer-reviewedDec 23, 2025

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Yanshu Wang, Amir Rattner, Zhongming Li…·Jeremy Nathans

This study shows that loss of TGF-beta signaling in vascular endothelial cells in mice causes choroidal neovascularization and CNS vascular inflammation, with significant immune cell infiltration and pro-inflammatory changes.

9 citations

mouseexperimental assay

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