Author

Adam Duckworth

Addenbrooke's HospitalORCID 0000-0002-8664-4987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Hyunchul JungiD· 1 shared Joseph E. ChambersiD· 1 shared Lily WuiD· 1 shared Matthew HoareiD· 1 shared Natalia BrzozowskaiD· 1 shared Peter J CampbelliD· 1 shared Stefan John MarciniakiD· 1 shared Tim H. H. CoorensiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

Hyunchul JungORCID

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1 paper

Recent·Most cited

Convergent evolution of somatic escape variants in SERPINA1 in the liver in alpha-1 anti-trypsin deficiency

Natalia Brzozowska, Lily Wu, Vera Khodzhaeva, William James Griffiths, Adam Duckworth, Hyunchul Jung, Tim H. H. Coorens, Yvette E. Hooks, Joseph E. Chambers, Peter J Campbell, Stefan John Marciniak, Matthew Hoare

The paper identifies convergent somatic escape variants in SERPINA1 in A1AT deficiency patients, showing adaptive mutations that counteract the disease-causing germline variant.

bioRxiv · Sep 2, 2024 · PreprintGenomics