Stefan John Marciniak

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

This paper introduces a method combining single-molecule light-field microscopy with widefield Fourier light-field microscopy to improve volumetric subcellular imaging and molecular diffusion analysis.

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

This study shows that interleukin-6 is critical in gcn2-mutation associated pulmonary vascular disease in mice, as its deletion rescues pulmonary hypertension phenotypes.

This study shows cigarette smoke induces PPP1R15A through oxidative stress, which reduces pro-inflammatory cytokine production in bronchial epithelial cells.

The paper identifies convergent somatic escape variants in SERPINA1 in A1AT deficiency patients, showing adaptive mutations that counteract the disease-causing germline variant.