Joseph E. Chambers

A GCN1-independent activator of the kinase GCN2

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

Programmable DNA-peptide nanostructures for multivalent regulation of intracellular signalling

This paper develops DNA-peptide nanostructures to multivalently inhibit TNKS, showing they effectively downregulate Wnt signaling in cancer cells despite differences in TBP copy number.

Volumetric single-molecule tracking inside subcellular structures

This paper introduces a method combining single-molecule light-field microscopy with widefield Fourier light-field microscopy to improve volumetric subcellular imaging and molecular diffusion analysis.

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

Convergent evolution of somatic escape variants in SERPINA1 in the liver in alpha-1 anti-trypsin deficiency

The paper identifies convergent somatic escape variants in SERPINA1 in A1AT deficiency patients, showing adaptive mutations that counteract the disease-causing germline variant.

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.