Hugh Edward Rickards

This study uses ultra-strong gradient MRI to show that myelin changes, not axon density, are linked to premanifest Huntington's disease, with mutation size correlating with myelin levels.

This study uses multi-compartment MRI signal analysis to quantify myelin breakdown in premanifest Huntington's disease, finding reduced myelin water fraction and age-related executive function decline.

The paper investigates genetic risk factors for psychiatric and cognitive symptoms in Huntington’s Disease using polygenic risk scores and finds associations between specific psychiatric risk scores and corresponding symptoms.