Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease
Chiara Casella, Elena Kleban, Anne Rosser, Elizabeth Jane Coulthard, Hugh Edward Rickards, Fabrizio Fasano, Claudia Metzler‐Baddeley, Derek Kenton Jones
This study uses multi-compartment MRI signal analysis to quantify myelin breakdown in premanifest Huntington's disease, finding reduced myelin water fraction and age-related executive function decline.
NeuroImage Clinical · Jan 1, 2021Peer-reviewedNeuroscience