Claudia Metzler‐Baddeley

Imaging brain vascular function in Cystic Fibrosis: an MRI study of cerebral blood flow and brain oxygenation

This study uses MRI to examine brain blood flow and oxygen metabolism in patients with cystic fibrosis, finding elevated cerebral metabolic rate of oxygen consumption compared to healthy controls.

Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making

This study links age-related decline in fornix fractional anisotropy to slower perceptual decision-making in older adults using a diffusion drift model and neuroimaging data.

Age-related changes in brain metabolites underlie slowing of speed-accuracy trade-off

This study investigates age-related changes in brain metabolites and microstructure that contribute to slower response times in older adults.

Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults.

The paper examines how APOE ε4 modifies obesity-related atrophy in hippocampal subfields of cognitively healthy adults using neuroimaging data.

Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington's disease: Evidence from in vivo ultra-strong gradient MRI

This study uses ultra-strong gradient MRI to show that myelin changes, not axon density, are linked to premanifest Huntington's disease, with mutation size correlating with myelin levels.

Dementia risk factors modify hubs but leave other connectivity measures unchanged in asymptomatic individuals: a graph theoretical analysis.

This study identifies a structural brain network hub in the right paracentral lobule associated with dementia risk factors in asymptomatic individuals, without affecting other graph theoretical measures.

Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease

This study uses multi-compartment MRI signal analysis to quantify myelin breakdown in premanifest Huntington's disease, finding reduced myelin water fraction and age-related executive function decline.

Drumming motor sequence training induces myelin remodelling in Huntington's disease: a longitudinal diffusion MRI and quantitative magnetization transfer study

This study examines if drumming training induces myelin remodelling in Huntington's disease patients using diffusion MRI and qMT imaging, finding increased MPF in specific white matter regions post-training.

Genetic risk of dementia modifies the impact of obesity on limbic white matter and spatial navigation behavior in cognitively healthy adults.

The causal structure of age-dependent limbic decline: fornix white matter glia damage causes hippocampal grey matter damage, not vice versa.

The paper investigates the causal relationship between white and gray matter damage in aging brains, finding that white matter damage causes gray matter decline, not the reverse.

Adipokines contribute to central-obesity related reductions in myelin-sensitive MRI indices in the fornix.

The paper examines how central obesity affects myelin-sensitive MRI metrics in the fornix and finds that visceral fat and adipokine ratios are linked to reduced myelin and increased inflammation.