Nitroxoline treatment of Balamuthia mandrillaris triggers genomic crisis, transcriptional collapse, and incomplete encystment via copper and iron chelation
Kaitlin A. Marquis, Natasha Spottiswoode, Angela M. Detweiler, Norma F Neff, Joseph L. DeRisi
This paper investigates how nitroxoline induces genomic instability, transcriptional collapse, and incomplete encystment in Balamuthia mandrillaris by chelating copper and iron.
bioRxiv · Feb 25, 2025 · PreprintMicrobiology