Angela M. Detweiler

The paper presents a single-cell long-read isoform atlas across 26 human tissues, revealing novel isoforms and their role in cellular identity and senescence.

This study identifies a conserved neural stem cell pool driving continuous CNS regeneration in Botryllus schlosseri, showing aging disrupts this process.

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

This study investigates age-related changes in germline stem cells (GSCs) in the protochordate Botryllus schlosseri using single-cell RNA sequencing and transplantation assays, revealing that GSCs, not gametes, drive reproductive aging.

This paper introduces a method to capture non-coding RNAs in single-cell RNA-seq, revealing new insights into gene regulation in immune cells, infected hepatocytes, and brain development.

The paper shows that pulsatile electrical current improves survival, regeneration, and reproduction in Botryllus schlosseri by altering stem cell and immune activity through transcriptomic changes.

This paper investigates how nitroxoline induces genomic instability, transcriptional collapse, and incomplete encystment in Balamuthia mandrillaris by chelating copper and iron.

The paper identifies a cell-type specific surveillance complex that represses cryptic promoters during differentiation in Drosophila male germ line stem cells.

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

The paper presents Zebrahub-Multiome, a single-cell multiomic atlas of zebrafish embryogenesis, revealing gene regulatory network dynamics and cis-regulatory elements across developmental stages.

This study uses single-nucleus RNA sequencing to analyze a mouse glioblastoma model, identifying potential therapeutic targets and similarities with human GBM subtypes.

The paper uses metagenomic sequencing to investigate a wildlife mortality event in songbirds, finding no single pathogen but highlighting the utility of metagenomics in such investigations.

Zebrafish embryos sequenced individually across ten developmental stages, paired with light-sheet lineage reconstruction, form an atlas and browser for in silico fate mapping.

DiMeLo-seq maps protein-DNA interactions genome-wide with single-molecule resolution by methylating DNA near binding sites and using long-read sequencing.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper identifies a SARS-CoV-2 N gene polymorphism that reduces RT-PCR assay sensitivity and emphasizes the need for multi-target testing.