Timothy S. Chisholm

Two Distinct Binding Modes Govern High-Affinity Ligand Interactions with Amyloid Fibrils

This study identifies two distinct binding modes for high-affinity ligand interactions with amyloid fibrils and demonstrates how these modes can inform ligand design improvements.

The Morphology of α-Synuclein Fibrils Changes during Formation, Storage, and upon Exposure to Ligands

This study investigates how α-synuclein fibril morphology changes during formation, storage, and exposure to ligands, showing continuous structural evolution and ligand-induced morphological shifts.