Sequence specificity of an essential nuclear localization sequence in Mcm3
Ziyi Wang, Yun Jing Zhang, Qian-yi Zhang, Kate Bilsborrow, Matthew Leslie, Raymond T. Suhandynata, Huilin Zhou
This study identifies the sequence specificity of Mcm3's NLS using mutagenesis and AlphaFold 3, showing that precise basic residue positioning is critical for nuclear import and chromatin loading.
PLoS Genetics · Jan 21, 2025Peer-reviewedMicrobiology