Raymond T. Suhandynata

Recognition of the centromere-binding protein Ndc10 by Scm3HJURP directs Cse4CENP-A deposition at native centromeres

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.

Antibiotic Exposure Through Human Milk Influences the Infant Gut Microbiome

This study examines how maternal antibiotic use during breastfeeding affects the infant gut microbiome and metabolome, finding altered microbial profiles and increased BMI in some infants.

Identification of Protein Cargo in Extracellular Vesicles from Macrophages in Progressing and Regressing Tumors

The paper identifies protein cargo in extracellular vesicles from tumor-associated macrophages in progressing and regressing tumors, revealing differences in protein composition based on culture duration and tumor state.

Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway

This study characterizes the Bub bacterial ubiquitination-like pathway, revealing its unique biochemical mechanisms and structural similarities to eukaryotic ubiquitination.

A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics

This study identifies fatty acid promoieties that improve CNS exposure of targeted protein degraders by enhancing pharmacokinetics and BBB permeability.

Sequence specificity of an essential nuclear localization sequence in Mcm3

This study identifies the sequence specificity of Mcm3's NLS using mutagenesis and AlphaFold 3, showing that precise basic residue positioning is critical for nuclear import and chromatin loading.

Concatemer Assisted Stoichiometry Analysis (CASA): a targeted mass spectrometry method for protein quantification

This paper introduces CASA, a targeted mass spectrometry method for protein quantification, and demonstrates its application in determining stoichiometries of kinetochore components in budding yeast.

SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

The paper shows SUMO factors regulate DPC repair pathways in yeast, promoting repair without Tdp1 but inhibiting it when Wss1 is absent.