Dongxin Lin

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.

This study identifies three novel germline variants associated with nasopharyngeal carcinoma risk and introduces a refined polygenic risk score linked to EBV infection.

The paper maps somatic mutations and clonal expansions in normal human tissues across nine organs, revealing organ-specific patterns of mutation accumulation and clonal evolution.

This paper improves polygenic risk scores by applying winners curse correction and variable thresholds to GWAS summary data, enhancing prediction accuracy for some diseases.