Author

Giorgos Hiotis

Tri-Institutional PhD Program in Chemical BiologyORCID 0000-0002-8731-7427Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Thomas WalziD· 2 shared Yoshitaka NakayamaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

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2 shared papersBiophysics

Thomas WalzORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 8, 2026

The MscS channel from Corynebacterium glutamicum uses a non-canonical gating mechanism

Yoshitaka Nakayama, Giorgos Hiotis, Thomas Walz

This study shows that CgMscS from Corynebacterium glutamicum opens at higher membrane tension than EcMscS and uses a distinct gating mechanism not based on the 'lipids-move-first' model.

DOI 10.64898/2026.09.02.748947

bacteria (other)structural biology

𝕏 PostBluesky

BiophysicsbioRxivPreprintMar 25, 2026

MscM uses a novel gating mechanism for bacterial mechanosensitive channels

Giorgos Hiotis, Thomas Walz

This study characterizes the structure and function of MscM, revealing that its cytoplasmic domain mediates channel gating through conformational changes, differing from other MscS-like channels.

DOI 10.64898/2026.03.24.713958

E. colicryo-EM

𝕏 PostBluesky