ActSeekN: A Structural-Motif-Based Pipeline for Interpretable Enzyme Function Annotation
Sandra Castillo, Chunhao Gu, Paula Jouhten, Peddinti V. Gopalacharyulu, O.H. Samuli Ollila
ActSeekN improves enzyme function annotation by using structural motifs from AlphaFold and UniProt data, outperforming existing methods in yeast, human, and Trichoderma reesei proteomes.
bioRxiv · Apr 28, 2026 · PreprintBioinformatics