FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety
Brian F. Corbett, Sandra Luz, Nathaniel P. Sotuyo, Jiah Pearson-Leary, Ganesh S. Moorthy, Athena F. Zuppa, Seema Bhatnagar
This study shows that FTY720 increases baseline HPA axis activity and reduces anxiety- and despair-like behaviors in rats by reducing angiogenesis in the medial prefrontal cortex.
bioRxiv · May 10, 2021Neuroscience