Oliver Stegle

The paper measures and compares transcriptional and epigenetic variability across immune cell types and finds neutrophils exhibit higher variability linked to immune pathways and environmental exposure.

The paper analyzes RNA splicing patterns in kidney renal clear cell carcinoma patients to identify tumor-specific isoforms and splicing quantitative trait loci associated with disease.

LIMIX improves GWAS power and phenotype prediction by enabling flexible multi-trait mixed models with multi-locus regression and handling large trait numbers.