NeurosciencePLoS ONEPeer-reviewed
Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimers disease reveal intraneuronal Abeta42 accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ flux dysregulation: Therapeutic implications
Viviana Soto‐Mercado, Miguel Mendivil‐Perez, Carlos Velez‐Pardo…·Marlene Jiménez-Del-Río
The paper models familial Alzheimer's disease using MSC-derived cholinergic-like neurons with PSEN1 E280A mutation, revealing key pathological features and potential therapeutic targets.
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